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Integrated Energy Metabolism and Oxygen Delivery Paradigm
1923 - 1929
The late 1920s period advances an integrated energy metabolism paradigm for exercise, where energy liberated by tissues is seen as bounded by oxygen supply and the efficiency of energy transformation into work. Aerobic and anaerobic pathways are treated as coupled determinants of performance, with energy budgeting interpreted through general physiology frameworks. Across species, studies foreground gas exchange and oxygen delivery to contracting muscles as central constraints shaping performance.
• Energy metabolism framework for exercise: multiple works converge on how aerobic and anaerobic processes, oxygen supply, and energy budgeting constrain muscular work, linking energy liberated to mechanical output within general physiology models [1], [3], [4], [11], [14], [17], [20].
• Oxygen transport and gas exchange as core determinants of exercised performance: arterial oxygen saturation, gas-exchange dynamics, and oxygen delivery to contracting muscles are studied across human and animal contexts [1], [6], [7], [9], [20].
• Anaerobic metabolism and lactic acid dynamics in muscle activity: focused investigations on lactic acid production, anaerobic energy, and their relation to endurance and performance [1], [3], [5], [16].
• Mechanical efficiency and maximum work in skeletal muscles: maximal force generation, energy cost, and efficiency are analyzed through mechanical and physiological lenses, including running resistance and muscular work [8], [9], [13], [14], [18], [19].
• Foundational general physiology and cross-species models: broad frameworks and comparative studies provide scaffolding for exercise physiology, integrating energy metabolism, respiration, and cellular processes [6], [10], [11], [12], [20].
Cardiorespiratory Metabolic Regulation
1930 - 1959
Measurement-Guided Exercise Physiology
1960 - 1989
Integrated Multisystem Exercise Physiology
1990 - 2000
Integrated Performance Physiology
2001 - 2007
Integrated Multi-Modal Exercise
2008 - 2014
Systemic Exercise Physiology
2015 - 2023